Nonlinear Dynamics: A Waters Company

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USA: +1 919 806 4401

Below are some key events in Nonlinear's history so you can see how we have evolved over the years. It's been an interesting, and at times a very exciting journey!


Nonlinear Dynamics, a Waters Company, releases Progenesis QI and Progenesis QI for proteomics with a public launch at Analytica 2014. These new products include new features whilst combining the functionality of two previously separate branded software products, Progenesis and TransOmics™ Informatics into one. This maintains the recognition of Progenesis as world-leading software for ‘omics data analysis and its support for all major instruments you may have now or in the future, including additional features specifically to support Waters customers.

Nonlinear expands its software development team with the recruitment of two new software engineers.


Nonlinear Dynamics becomes part of Waters Corporation. Nonlinear continue to operate from their headquarters in Newcastle on Tyne; developing, selling and supporting Progenesis LC-MS for proteomics and Progenesis CoMet for metabolomics/lipidomics. As part of the acquisition the sales and support of Progenesis SameSpots software for 2D gel electrophoresis image analysis are transferred to our sister company, TotalLab.

Nonlinear expands its customer support team with the recruitment of a new customer support coordinator.

Progenesis LC-MS v4.1 is released with automatic reference run selection then alignment of imported runs and alignment quality scores reported.

Progenesis CoMet v2.0 is launched to market with automatic deconvolution of compound ions, an integrated search tool and improvements to the workflow.


Nonlinear releases Progenesis ClearSpec which deisotopes and charge deconvolutes thousands of high-resolution MS/MS spectra in seconds. It has multiple uses including protein characterisation studies, increasing reliability and accuracy of peptide and protein database searches and helping researchers build high quality spectral libraries.

Nonlinear expands its development team with the recruitment of 3 new software developers and a new software tester.

A new Omics research platform from Waters is launched, which is developed by Nonlinear Dynamics and powered by Progenesis. The Waters TransOmics™ Informatics for Proteomics and TransOmics™ Informatics for Metabolomics software launches were announced at the 60th ASMS Conference in Vancouver, Canada.

Progenesis CoMet v2.0 beta is released which includes compound ion deconvolution and improvements to the workflow.


Progenesis SameSpots version 4.5 is released which allows users to link protein search results to spot data and put their 2D analysis into biological context.

Nonlinear moves into a larger office space in Keel House (Newcastle upon Tyne, UK) to allow for expansion of the team. Nonlinear USA Inc also relocates to new offices in Durham, NC.

Nonlinear unveils version 4.0 of Progenesis LC-MS with an extended workflow for the quantification and identification of proteins which includes multivariate statistics.

Nonlinear releases Progenesis CoMet v1.0, a new product developed to measure the relative abundances of metabolites through the analysis of LC-MS.


Progenesis LC-MS v3.0 is released including a workflow to analyse fractionated samples, the ability to normalise based on a sub-set of known peptide ions, import results from Scaffold (Proteome Software) and exclude non-unique peptides from protein quantification.

Progenesis SameSpots v4.0 is released with a new experimental design option as well as additional features to help manage data quality. It's followed later in the year by v4.1, which incorporates the SpotCheck workflow for monitoring the reproducibility of gel running.

Progenesis LC-MS v2.6 is released, with enhanced support for quality control, greater integration with external hardware and data formats, and further enhancements to peak detection.

Nonlinear starts 2010 with a new look for the company and Progenesis product range and a new, improved website.


A new management team is appointed to drive forward the Phoretix and TotalLab product ranges which are developed and marketed by TotalLab Ltd - a company spun out of Nonlinear Dynamics.

Nonlinear releases new versions of the Progenesis range, developed to enable reproducible proteomics research - Progenesis LC-MS v2.0, Progenesis SameSpots v3.3 and Progenesis MALDI v1.2 are showcased at the Proteomic Forum, Berlin

Progenesis SameSpots v3.0 outperforms GE Healthcare's Decyder and Syngene's Dymension in study published in the Journal of Proteome Research

Nonlinear's headquarters relocates to brand new, high-specification offices in the centre of Newcastle-upon-Tyne


Release of Progenesis MALDI v1.0 for biomarker discovery using MALDI-TOF or SELDI analysis

Distribution agreement with GeneBio for the Phenyx MS identification platform

New OEM agreement with UVP, LLC for the SameSpots 2D image analysis software

Nonlinear enters the label-free, quantitative LC-MS analysis market with the launch of Progenesis LC-MS v1.0

Launch of the new 21 CFR part 11 module for the TotalLab 1D gel analysis range

Release of Progenesis SameSpots v3.0 - the 2D analysis software that enabled the HUPO Reproducibility Study


Nonlinear Dynamics create the Fixing Proteomics Campaign, a community effort with endorsement from key opinion leaders, supporting best practices to help proteomics deliver in the future

National Cancer Research Institute, Japan validate predictive biomarkers on a clinical scale using Nonlinear Dynamics' SameSpots technology

Nonlinear Dynamics appoint Dr. Paul Goulding as Distributor Manager to expand sales in the Far East


Hoefer, Inc. signs agreement with Nonlinear Dynamics to distribute the TotalLab range of image analysis solutions

Nonlinear Dynamics Enter Co-Marketing Agreement with Agilent

Nonlinear Dynamics' Progenesis SameSpots becomes fastest selling 2D software in the company history

Nonlinear Dynamics create Progenesis SameSpots, a new approach to 2D image analysis incorporating TT900 S2S

HUPO and Nonlinear launch the HUPO 5th Annual World Congress, Long Beach 2006 website

NE BioGroup to distribute TotalLab range throughout the US


Announce the release of the new 'Technologies' range, the first product, TT900 S2S is launched with immediate success - first copy licensed by the University of Newcastle upon Tyne

Nonlinear enters the Biomarker Discovery market with PG600

Invitrogen Corporation and Nonlinear sign distribution agreement

Enters co-development and co-marketing agreement with Waters Corporation

Nonlinear undertakes a global corporate re-brand and announces the launch of the new TotalLab TL and Progenesis PG range of products

Collaborates with The Human Proteome Organisation (HUPO) to develop and support their online activities

Extends OEM partnership with PerkinElmer to incorporate the full Nonlinear analysis range


Awarded the prestigious 'Product Line Innovation Award 2004' by Frost and Sullivan

Listed again in the Deloitte Fast 50 and Sunday Times Fast Track 100

Announce a third consecutive year of record turnover

Signs global OEM agreement with Shimadzu Corporation


Second year in top ten of Deloitte Fast 50 for the North, also ranked in Sunday Times Fast Track 100

Genomic Solutions signs OEM distribution agreement with Nonlinear Dynamics

Second year of record sales and further profits

Decides not to renew OEM contract with proteomics group at Amersham Biosciences

PerkinElmer, Inc signs new OEM distribution agreement

Releases Progenesis Discovery Informatics - University of Texas Medical Branch at Galveston immediate customer


Collaborates with Amersham Biosciences with exclusive software deal for ImageQuant TL™

Extends range of software for 2D electrophoresis image analysis

Receives Exceptional SMART award and SMART Achievement Award

Expands Asian Pacific representation with new distributors and Asia Pacific General Manager

Collaborates with Amersham Biosciences to automate protein picking from bands in 1-D electrophoresis gels


PerkinElmer - OEM agreement for Progenesis™

Amersham Pharmacia Biotech - OEM agreement for Progenesis™

Expands US subsidiary

Releases Progenesis™, unique Bioinformatics solution


Incorporation of US subsidiary, Nonlinear USA Inc.


Makes a profit for the fifth consecutive year

Releases multi-application analysis product, TotalLab™


Receives fourth DTI-sponsored SMART award

Releases a new product range for the analysis of arrays

Accredited to ISO-9001 / TickIT


Receives "Outstanding Business Development" award


Signs OEM deal with Pharmacia Biotech to sell its products as "ImageMaster™"

Releases 1D and 2D Database products


Increases turnover by 300%

First OEM deal, with Bio-Rad Laboratories Inc.


Releases first product for analysing 1D electrophoresis gels


Phoretix™ 2D first released to great acclaim


Will Dracup founds Nonlinear Dynamics