The intuitive and unbiased workflow of Progenesis LC-MS makes the labor-intense data evaluation much more efficient. The support of the mz-XML data format enables the analysis of datasets acquired on many different MS instruments, eliminating the dependency on specialized vendors' software.
Evidence Progenesis LC-MS works
Examples from different labs around the world, as well our own research and development, demonstrating how Progenesis LC-MS supports quantitative proteomics research. If you want to share how you use Progenesis LC-MS let us know and we can include it here.
LC-MS in action
What can be achieved using label-free LC-MS and Progenesis LC-MS.
Label-free LC-MS provides a range of benefits compared to other techniques, including those that use labelling. Read...
"Quantification by MS intensity (Progenesis LC-MS) clearly outperformed spectrum counting. Only 0.5% of all intensity values (661 out of 133,042) were missed in the Progenesis data, while 52.2% (26,751 out of 51,272) of all spectrum counting values were zero."
Comparison of label-free protein quantification approaches for chemical proteomics. Zhixiang Wu, Kurt Fellenberg, Simone Lemeer and Bernhard Kuster. 58th ASMS Conference on Mass Spectrometry and Allied Topics. Utah, USA. May 2010
Technical & Application notes
Technical details on analysis steps as well as applications that you can add to your research.
Technical Note: How does Progenesis LC-MS measure protein quantification? (1MB)
Application Note: How to achieve reliable quantitative proteomics using low resolution ion trap data (854KB)
Application Note: Increase proteome coverage with informatics-based gas-phase fractionation (850KB)
