Inter-lab reproducibility with CV’s < 20% for top 30 differentially expressed proteins
Progenesis SameSpots helps you overcome the biggest challenge facing everyone in quantitative proteomics today, cross-lab reproducibility of results. If you can achieve this then you can be confident in measuring real biological effects that can make a difference, not just reporting artefacts of an experimental approach. Progenesis LC-MS applies a similar unique approach so we hope it can show the same benefits and cross-lab reproducibility with your quantitative MS proteomics analysis.
ProteoRed Reproducibility Study
A multi-laboratory study was performed by ProteoRed (Spanish network of proteomics facilities) and the results analysed by Progenesis SameSpots. Some of the data is represented below but you can see the full results from (#77) presented at the ABRF 2009 conference (883KB) and a poster with more details (223KB) presented by Francesc Canals for ProteoRed in 2008.
How does Progenesis achieve this?
The unique Progenesis workflow perfectly aligns data prior to analysis allowing all detected features to be 100% matched and compared directly across every run without the need to validate or edit each individual feature. This means you can quickly see the real expression differences without laborious, subjective editing and make valid conclusions using multivariate statistics applied to a complete data set.